Skip to main content
. Author manuscript; available in PMC: 2024 Oct 13.
Published in final edited form as: Vaccine. 2023 Sep 14;41(43):6461–6469. doi: 10.1016/j.vaccine.2023.08.071

Figure 1. Optimal virulence as a product of host survival and transmission probability.

Figure 1.

While transmission probability increases with higher SPVL (blue line), host survival decreases (green line). In this conceptual figure, fitness is optimized when these lines intersect. We hypothesize that a disease modifying vaccine that extends host survival (dotted green line) could select for viruses with higher SPVLs.