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. 2023 Nov 8;8(21):e168596. doi: 10.1172/jci.insight.168596

Figure 1. Repeated topical application of OVA combined with RW pollen shells elicits eosinophilic conjunctivitis.

Figure 1

(A) Giemsa staining of the conjunctival tissue at ×200 magnification. Scale bars: 50 μm (lower magnification) and 10 μm (insets). Arrowheads denote eosinophils. (B–D) Conjunctival eosinophil populations among CD45+ cells (B and C) and cell numbers of indicated populations in the conjunctiva (D). Pooled results of 2 independent experiments (n = 8–18). Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by 2-tailed Kruskal-Wallis test with Dunn’s multiple-comparison test. (E) Pearson’s correlation between CD4+ST2+ T cell and eosinophil numbers in the conjunctiva. The B6 mouse strain was used for all experiments.