Figure 2. hPF4 and KKO inhibit thrombin generation but not fibrinolysis.

(A and B) Thrombin generation studies of DNase I–digested LMW NETs (A) and DNA (B) in the absence or presence of hPF4 (20 μg/mL) and/or KKO (10 μg/mL). (C and D) Time to 50% clot lysis of LMW NET–induced (C) and LMW DNA–induced (D) coagulation, as determined based on kinetic curves. Data are mean ± SEM of at least 3 independent experiments. Comparative statistical analysis was performed by Kruskal-Wallis 1-way ANOVA.