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. 2023 Nov 22;8(22):e169554. doi: 10.1172/jci.insight.169554

Figure 3. Conservation of NPY1R/CCK, NPY1R/GRP, and NPY1R/NPFF subpopulations in the superficial dorsal horn of nonhuman primates and humans.

Figure 3

(A–F) NPY1R in the substantia gelatinosa extensively colocalizes with superficial CCK (CCK/NPY1R 22.49% ± 3.08%; NPY1R/CCK 72.45% ± 4.53%), GRP (GRP/NPY1R 27.26% ± 1.63%; NPY1R/GRP 86.46% ± 1.70%), and NPFF (NPFF/NPY1R 41.98% ± 2.20%; NPY1R/NPFF 93.82% ± 1.12%) in the rhesus macaque (n = 2 macaques). Individual data points represent 1 single quantified section. Scale bars: 25 μm. (G–I) NPY1R colocalizes with superficial CCK, NPFF, and GRP in the human spinal cord dorsal horns (n = 2 human organ donors). Scale bars: 20 μm. Yellow arrows indicate colocalization. Data shown as mean ± SEM.