Table 2.
Multivariate logistic regression analyses of fracture according to tertile categories of the S1P concentration and fracture risk assessment tool probabilitya)
| Adjusted variables | Tertiles of TBS | Tertiles of TBS and FRAX probability | ||
|---|---|---|---|---|
|
|
|
|||
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| S1P concentration | ||||
| T1 (S1P <2.24 μmol/L) | Ref | Ref | ||
| T2 (2.24 μmol/L ≤S1P <3.30 μmol/L) | 3.21 (1.41–7.31) | 0.005 | 3.31 (1.38–7.90) | 0.007 |
| T3 (S1P ≥3.30 μmol/L) | 4.16 (1.76–9.82) | 0.001 | 3.13 (1.28–7.66) | 0.013 |
|
| ||||
| FRAX probabilitya) | ||||
| T1 (FRAX probability <3.98%) | NA | Ref | ||
| T2 (3.98% ≤FRAX probability <5.18%) | NA | 6.07 (1.94–18.98) | 0.002 | |
| T3 (FRAX probability ≥5.18%) | NA | 12.90 (4.16–39.98) | <0.001 | |
P<0.05 is statically significant. Bold values indicate statistical significance.
a)
The FRAX probability was calculated using CRFs and FN-BMD by the FRAX. CRFs were sex, age, body mass index, current smoking, alcohol intake (≥3 U/day), other causes of secondary osteoporosis, and parental history of hip fracture.
TBS, trabecular bone score; FRAX, fracture risk assessment tool; CRFs, clinical risk factors; FN-BMD, femur neck-bone mineral density; OR, odds ratio; CI, confidence interval; S1P, sphingosine 1-phosphate; Ref, reference; NA, not available.