Table 5.

Risk of all-cause and breast cancer-specific mortality in association with therapies for cancer, hypertension and diabetes by age and race/ethnicity

	Hazard ratio (95% CI) of all-cause mortality*			Hazard ratio (95% CI) of breast cancer-specific mortality*
	Model-1	Model-2	Model-3	Model-1	Model-2	Model-3
Age (years)
65–69	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
70–74	1.28 (1.22–1.33)	1.23 (1.17–1.28)	1.20 (1.15–1.26)	1.12 (1.05–1.19)	1.12 (1.05–1.19)	1.22 (1.06–1.19)
75–79	1.91 (1.83–1.99)	1.75 (1.68–1.82)	1.66 (1.59–1.73)	1.45 (1.36–1.54)	1.40 (1.32–1.50)	1.39 (1.31–1.48)
80–89	3.79 (3.65–3.93)	2.81 (2.71–2.92)	2.55 (2.45–2.65)	5.65 (5.25–6.08)	1.78 (1.69–1.89)	1.73 (1.63–1.83)
90 or older	8.93 (8.50–9.37)	4.51 (4.29–4.75)	3.87 (3.67–4.08)	2.48 (2.35–2.62)	2.48 (2.29–2.68)	2.29 (2.12–2.48)
Race/ethnicity
Whites	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Blacks	1.46 (1.41–1.52)	1.10 (1.06–1.15)	1.01 (0.97–1.06)	1.64 (1.55–1.74)	1.16 (1.09–1.23)	1.08 (1.01–1.15)
Asians/Pacific Islanders	0.66 (0.62–0.71)	0.74 (0.68–0.79)	0.71 (0.66–0.77)	0.70 (0.63–0.77)	0.80 (0.71–0.90)	0.79 (0.71–0.89)
Others	0.66 (0.56–0.78)	0.58 (0.49–0.68)	0.56 (0.47–0.66)	0.69 (0.53–0.88)	0.52 (0.40–0.67)	0.52 (0.40–0.67)
Chemotherapy
No	1.00 (reference)	-	1.00 (reference)	1.00 (reference)	-	1.00 (reference)
Yes	1.02 (0.98–1.05)	-	0.72 (0.69–0.75)	1.72 (1.64–1.80)	-	0.77 (0.73–0.81)
Radiotherapy
No	1.00 (reference)	-	1.00 (reference)	1.00 (reference)	-	1.00 (reference)
Yes	0.36 (0.35–0.37)	-	0.65 (0.63–0.67)	0.35 (0.34–0.37)	-	0.72 (0.69–0.75)
Hormone therapy
Hormone receptor (HR) negative	1.00 (reference)	-	1.00 (reference)	1.00 (reference)	-	1.00 (reference)
HR positive-did not receive hormone therapy	1.63(1.57–1.69)	-	1.33 (1.28–1.38)	2.41 (2.28–2.53)	-	1.57 (1.49–1.66)
HR positive-received hormone therapy	0.92 (0.89–0.94)	-	0.73 (0.70–0.75)	0.90 (0.85–0.94)	-	0.68 (0.65–0.71)
Unknown/missing	2.81(2.70–2.92)	-	1.49 (1.42–1.56)	4.24 (4.00–4.48)	-	1.69 (1.57–1.81)
Hypertension treatment
No Hypertension	1.00 (reference)	-	1.00 (reference)	1.00 (reference)	-	1.00 (reference)
Hypertension – no treatment	1.44 (1.38–1.50)	-	1.13 (0.93–1.38)	1.12 (1.06–1.19)	-	1.06 (0.80–1.40)
Hypertension – received treatment	1.58 (1.53–1.64)	-	1.13 (0.93–1.37)	1.01 (0.96–1.07)	-	0.97 (0.73–1.28)
Diabetes treatment
No diabetes	1.00 (reference)	-	1.00 (reference)	1.00 (reference)	-	1.00 (reference)
Diabetes – no treatment	1.46 (1.41–1.51)	-	0.93 (0.76–1.13)	1.03 (0.98–1.08)	-	0.89 (0.67–1.18)
Diabetes – received treatment	2.09 (2.00–2.18)	-	1.20 (0.99–1.46)	1.26 (1.18–1.35)	-	0.96 (0.73–1.26)

^*Model-1 was a crude model without adjusting for other factors. Model-2 adjusted for age, marital status, health insurance, tumor stage, size, grade, year of diagnosis, SEER registries, surgery, and comorbidity score. Model-3 adjusted for chemotherapy, radiation therapy, hormone therapy, antihypertensive therapy, and antidiabetic therapy, in addition to other factors in Model-2