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. 2023 Dec 14;14:8338. doi: 10.1038/s41467-023-43527-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Deletion of Haao (Haao^-/-, KO; N = 45) extends lifespan relative to wild type (N = 37) in C57BL/6N mice. Kaplan-Meier survival curves show lifespan from birth. Gray text indicates change in mean lifespan. b Haao^-/- mice have lower body weight in early- to mid-adulthood. c Haao deletion increases 3HAA concentration in plasma and urine. d Haao^-/- mice had significantly increased grip strength at 12 and 18 months of age. ^#p < 0.1, ^†, *p < 0^.05, ^‡, **p < 0.01, ***p < 0.001 vs. control diet (log rank test, panel a; two-sided Welch’s t test, panels b–d). Error bars indicate standard error of mean. Summary statistics are provided in Supplementary Data 1 and source data are provided in Source Data.