Table 3.

Impact of the transformation pipeline on K–L divergence and area under the receiver operating curve (AUC).

Method	Simulation methods					Assessment metrics
	Blur synthesis module				Contrast reduction module
	Gamma correction	Fiber core smoothing	Noise injection	Saturation preservation		K–L divergence	AUC
1	+	+	+	+	+	0.211	0.87
2	−	+	+	+	+	0.186	0.87
3	+	−	+	+	+	0.248	0.88
4	+	+	−	+	+	0.188	0.88
5	+	+	+	−	+	0.201	0.85
6	+	+	+	+	−	0.376	0.95
Original dataset	−	−	−	−	−	0.433	0.96

A positive sign (+) indicates when a module was present, and a negative sign (−) indicates when a module was absent. K–L divergence Kullback–Leibler divergence, AUC area under the receiver operating characteristic curve.