Fig. 1.

Study workflow and scheme of publication selection with information on patients with two or more ARVC-related desmosomal variants and subsequent patient selection for the database. *61 out of the 65 articles overlapped with the systematic PubMed search, ^number of patients after including information from contacted authors. Patient groups are based on the number of (likely) pathogenic ARVC variants after reclassification; P, pathogenic variant; LP, likely pathogenic variant; VUS, variant with uncertain significance; LB, likely Benign variant; B, benign variant