Fig. 4.
Gene categories harboring rare deleterious variants stratified by age. The forest plot shows the log odds ratio comparing proportion of variant carriers between 471 pediatric and 926 adult patients for different gene categories across cardiomyopathy subtypes. Sarcomere genes were more frequently mutated in pediatric HCM cases while channelopathy genes were more frequently mutated in adult DCM patients. Filled circles indicate significant differences between pediatric and adult patients (p < 0.05). CMP, cardiomyopathy (black); DCM, dilated cardiomyopathy (blue), HCM, hypertrophic cardiomyopathy (red)