Table 1.

Randomized trials evaluating post-lumpectomy radiation benefit in older patients.

Study	Inclusion age criteria (years)	T-size	Randomization	# patients	Local relapse (%) p value; F/U years		Distant relapse (n = no. of patients) or (%)		Overall survival (%) p value; F/U years
Study	Inclusion age criteria (years)	T-size	Randomization	# patients	ET + RT	ET	ET + RT	ET	ET + RT	ET
CALGB 9343 JCO 2013	≥ 70 years	≤ 2cm	ET vs ET + RT	636	2%	10%	n = 17	n = 10	67%	66%
CALGB 9343 JCO 2013	≥ 70 years	≤ 2cm	ET vs ET + RT	636	p < 0.001; 10-years		10-years		p = 0.64; 10-years
ABCSG 8A Trial Int. J. Rad. Biol Phy 2007	≥ 50 years	< 3cm	ET vs ET + RT	831	2.5%	7.6%	n = 16	n = 12	86.6%	87.6%
ABCSG 8A Trial Int. J. Rad. Biol Phy 2007	≥ 50 years	< 3cm	ET vs ET + RT	831	p = 0.0004; 10-years		10-years		No difference p = 0.18; 10-years
Canadian Trial NEJM 2004	≥ 50 years	≤ 5cm	ET vs ET + RT	769	0.6%	7.7%	4.5%	4%	93.2%	92.8%
Canadian Trial NEJM 2004	≥ 50 years	≤ 5cm	ET vs ET + RT	769	p = <0.001; 8-years		8-years		No difference p = 0.69; 8-years
PRIME II NEJM 2023	≥ 65 years	≤ 3cm	ET vs ET + RT	1326	0.9%	9.8%	0.5%	1%	81%	80.4%
PRIME II NEJM 2023	≥ 65 years	≤ 3cm	ET vs ET + RT	1326	p = 0.0008; 10-years		5-years		No difference (p = 0.34; 10-years)