Table 4.

Compliance to therapeutic course of endocrine therapy.

Author	# patients	Patient group	Non-compliance	Contributing factors
He et al., JCO 2015	3395 Survey	Pre and postmenopausal	14%@ 1 year 36% @ 3 years 54% @ 5 years	Older age Comorbidity Need analgesics & sedatives
Salgado et al., Br. C. Res Treat 2007	622 Survey	Postmenopausal	30%	84% because of adverse effects
Sheppard et al., JCO 2014	1288 Interviews	≥ 65 years	51.5%	Frail Health Older age Race, Stage
Hirshman et al., JCO 2010	8769 Database	42% ≥ 65 years	51% @ 4.5 years	Age (older and younger groups) Higher comorbidity