Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 14;14:8341. doi: 10.1038/s41467-023-44089-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — During Pol II pausing at EGR1, ELK1 and ERK2 are inactive. TOP2B is ubiquitinated by the BRCA1/BARD1 complex (purple/pink circles)⁴⁷. Upon transcriptional activation, ERK2 is activated to phosphorylate ELK1 and TOP2B (phosphorylation marked with a black star and a letter “P”). TOP2B generates DNA bending, relaxes DNA supercoiling, mediates DNA strand break (DSB), triggering DNA damage response signaling that phosphorylates and activates multiple enzymes (tan circles) including PI3K, TRIM28, and BRCA1^4,21,47. If ERK2 is catalytically null or absent, gene activation is hindered and TOP2B is abnormally increased in the EGR1 TSS. Nascent RNA, an orange curved line.