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. 2023 Nov 6;69(6):328–336. doi: 10.1262/jrd.2023-021

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©2023 Society for Reproduction and Development

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Changes in reproductive performance and ovarian histology associated with aging. (A) Reproductive performance of female mice at 2–4 and 8–10 months of age. The average number of pups per litter (Pups/litter, left panel), the number of litters per two-month period (Litter/period, middle panel), and the total number of pups delivered during the test period (2–4 and 8–10 months) (Total number of pups, right panel) are shown (n = 9). * P < 0.05. (B) Representative hematoxylin-eosin-stained ovarian sections from young and aged breeder models (n = 9 and 5, respectively). Lower- and higher-magnification photographs are shown in the upper and lower panels, respectively. The regions shown in the lower panels are indicated with dashed line squares in the upper panels. Arrowhead indicates multinucleated and enlarged macrophages located in the stroma. AF, antral follicle; CL, corpus luteum. (C) The autofluorescence of stromal macrophages was observed (n = 3). Left panel, bright field; right panel, autofluorescence observed using a 470-nm filter.