Table 3.
Sensitive analyses for genetically proxied inhibition of HMGCR, NPC1L1, or PCSK9.
| Outcome | P value for MR-Egger intercept | MR Egger P-value for Cochran Q test | Inverse variance weighted P-value for Cochran Q test | P value for MR-PRESSO global test |
|---|---|---|---|---|
| HMGCR | ||||
| Erectile dysfunction | 0.949 | 0.754 | 0.851 | 0.879 |
| Coronary heart disease | 0.272 | 0.675 | 0.585 | 0.574 |
| NPC1L1 | ||||
| Erectile dysfunction | 0.386 | 0.841 | 0.348 | NA |
| Coronary heart disease | 0.728 | 0.967 | 0.901 | NA |
| PCSK9 | ||||
| Erectile dysfunction | 0.445 | 0.130 | 0.141 | 0.164 |
| Coronary heart disease | 0.757 | 0.079 | 0.109 | 0.134 |