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. 2023 Dec 14;14:7812. doi: 10.1038/s41467-023-43510-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Serial dilutions of venoms (2.5–200 µg/mL) were pre-incubated with the MTC_½ of DMPS, marimastat, varespladib, or vehicle control for 30 minutes, after which HaCaT cells were exposed to the treatments for 24 hours followed by MTT cell viability assays, from which venom concentration-response curves and their associated IC₅₀ values were calculated. Panels show venom from a B. arietans, b C. atrox, c E. carinatus, d E. ocellatus, e East African N. nigricollis, and f West African N. nigricollis. * Signifies that the IC₅₀ is significantly higher than that of the vehicle control for that venom as determined by a one-way ANOVA followed by Dunnett’s multiple comparisons test (P < 0.05, n = 3 biologically independent cell experiments). ANOVA statistics for individual statistically analysed graphs are: a F(3,8) = 1.057, P = 0.4195; b F(3,8) = 37.16, P = 0.000048; c F(3,8) = 21.17, P = 0.0004; d F(3,8) = 20.34, P = 0.0004; e F(3,8) = 8.757, P = 0.0066; f F(3,8) = 2.998, P = 0.0952. Data are presented as mean values ± SD and the individual values for each trial are shown as points within each of the bar graphs. Source data are provided as a Source Data file.