Table 5. The ROC curve of cardiovascular metrics on CTPA under the 2015 and 2022 ESC/ERS diagnostic criteria.
| Cardiovascular metric on CTPA | Cutoff value | AUC | 95% CI | P value | Sensitivity | Specificity | |
|---|---|---|---|---|---|---|---|
| Lower limit | Upper limit | ||||||
| CTPA metric for mPAP >20 mmHg | |||||||
| Cobb angle (degree) | 48.3 | 0.872±0.026 | 0.822 | 0.922 | <0.001** | 0.67 | 1.00 |
| MPAd (mm) | 30.4 | 0.934±0.021 | 0.892 | 0.976 | <0.001** | 0.88 | 0.90 |
| RVtd (mm) | 43.3 | 0.876±0.025 | 0.827 | 0.925 | <0.001** | 0.69 | 1.00 |
| RAtd (mm) | 49.7 | 0.819±0.033 | 0.755 | 0.883 | <0.001** | 0.69 | 0.86 |
| RVa (mm2) | 24.5 | 0.842±0.031 | 0.781 | 0.904 | <0.001** | 0.72 | 0.86 |
| RAa (mm2) | 15.4 | 0.808±0.034 | 0.742 | 0.875 | <0.001** | 0.83 | 0.66 |
| RVWT (mm) | 3.8 | 0.910±0.025 | 0.861 | 0.959 | <0.001** | 0.90 | 0.80 |
| MPAd/AAd ratio | 0.98 | 0.873±0.027 | 0.821 | 0.925 | <0.001** | 0.76 | 0.84 |
| RVtd/LVtd ratio | 0.99 | 0.860±0.028 | 0.806 | 0.914 | <0.001** | 0.84 | 0.80 |
| RVa/LVa ratio | 0.93 | 0.870±0.026 | 0.819 | 0.920 | <0.001** | 0.79 | 0.84 |
| RVWT/IVST ratio | 0.40 | 0.925±0.020 | 0.886 | 0.964 | <0.001** | 0.90 | 0.80 |
| Prediction model | – | 0.979±0.009 | 0.961 | 0.996 | <0.001** | – | – |
| CTPA metric for mPAP ≥25 mmHg | |||||||
| Cobb angle (degree) | 46.2 | 0.892±0.023 | 0.847 | 0.937 | <0.001** | 0.77 | 0.87 |
| MPAd (mm) | 30.4 | 0.918±0.025 | 0.869 | 0.967 | <0.001** | 0.92 | 0.84 |
| RVtd (mm) | 43.3 | 0.900±0.023 | 0.854 | 0.946 | <0.001** | 0.73 | 0.97 |
| RAtd (mm) | 49.7 | 0.822±0.032 | 0.760 | 0.885 | <0.001** | 0.72 | 0.82 |
| RVa (mm2) | 24.5 | 0.868±0.028 | 0.813 | 0.924 | <0.001** | 0.77 | 0.87 |
| RAa (mm2) | 15.8 | 0.802±0.033 | 0.737 | 0.868 | <0.001** | 0.86 | 0.66 |
| RVWT (mm) | 3.8 | 0.843±0.032 | 0.780 | 0.906 | <0.001** | 0.89 | 0.66 |
| MPAd/AAd ratio | 0.98 | 0.856±0.030 | 0.798 | 0.915 | <0.001** | 0.78 | 0.77 |
| RVtd/LVtd ratio | 0.99 | 0.882±0.025 | 0.833 | 0.930 | <0.001** | 0.87 | 0.85 |
| RVa/LVa ratio | 0.92 | 0.898±0.022 | 0.854 | 0.942 | <0.001** | 0.85 | 0.80 |
| RVWT/IVST ratio | 0.45 | 0.891±0.024 | 0.844 | 0.938 | <0.001** | 0.85 | 0.77 |
| Prediction model | – | 0.964±0.014 | 0.936 | 0.992 | <0.001** | – | – |
Prediction model = Cobb angle + MPAd + RVtd + RVWT. Continuous variables are expressed as mean value ± standard deviation. **, P<0.001 is considered statistically significant. ROC, receiver operator characteristic curve; CTPA, computed tomography pulmonary angiography; ESC, European Society of Cardiology; ERS, European Respiratory Society; AUC, area under ROC curve; CI, confidence interval; mPAP, mean pulmonary arterial pressure; MPAd, diameter of the main pulmonary artery; RVtd, transverse diameter of the right ventricle; RAtd, transverse diameter of the right atrium; RVa, area of the right ventricle; RAa, area of the right atrium; RVWT, right ventricular free wall thickness; AAd, diameter of the ascending aorta; LVtd, transverse diameter of the left ventricle; LVa, area of the left ventricle; IVST, interventricular septal thickness.