Table 2. Diagnostic performance of diffusion metrics in differentiating LrGGs from GBMs.
| Metric | AUC (95% CI) | Cutoff value | Sensitivity (%) | Specificity (%) | IDI |
|---|---|---|---|---|---|
| ALPS-index | 0.794 (0.694–0.895) | 1.381 | 72.22 | 80.00 | – |
| FA | 0.614 (0.486–0.741) | 0.138 | 52.78 | 71.11 | – |
| FA + ALPS-index | 0.823 (0.731–0.915) | – | 80.56 | 73.33 | 0.237 (P<0.001) |
| MD | 0.807 (0.709–0.905) | 1.054 | 72.22 | 86.67 | – |
| MD + ALPS-index | 0.854 (0.774–0.935) | – | 83.33 | 80.00 | 0.123 (P=0.004) |
| MK | 0.794 (0.696–0.893) | 0.514 | 86.11 | 64.44 | – |
| MK + ALPS-index | 0.854 (0.772–0.935) | – | 91.67 | 71.11 | 0.115 (P=0.005) |
MD is in units of 10−3 mm2/s. LrGG, lower-grade glioma; GBM, glioblastoma; AUC, area under the curve; CI, confidence interval; IDI, integrated discrimination index; ALPS, analysis along the perivascular space; FA, fractional anisotropy; MD, mean diffusivity; MK, mean kurtosis.