Table 4. Diagnostic performance of diffusion metrics for IDH1 mutation status discrimination in LrGGs.
| Metric | AUC (95% CI) | Cutoff value | Sensitivity (%) | Specificity (%) | IDI |
|---|---|---|---|---|---|
| ALPS-index | 0.737 (0.544, 0.931) | 1.406 | 87.88 | 66.67 | – |
| FA | 0.707 (0.540, 0.874) | 0.117 | 60.61 | 75.00 | – |
| FA + ALPS-index | 0.788 (0.632, 0.943) | – | 63.64 | 83.33 | 0.160 (P=0.045) |
| MD | 0.753 (0.581, 0.924) | 1.093 | 87.88 | 58.33 | – |
| MD + ALPS-index | 0.861 (0.710, 1.000) | – | 90.91 | 83.33 | 0.236 (P=0.002) |
| MK | 0.778 (0.603, 0.953) | 0.496 | 69.70 | 83.33 | – |
| MK + ALPS-index | 0.846 (0.685, 1.000) | – | 90.91 | 83.33 | 0.146 (P=0.017) |
MD is in units of 10−3 mm2/s. IDH1, isocitrate dehydrogenase 1; LrGG, lower-grade glioma; AUC, area under the curve; CI, confidence interval; IDI, integrated discrimination index; ALPS, analysis along the perivascular space; FA, fractional anisotropy; MD, mean diffusivity; MK, mean kurtosis.