Table 3. Metabolite concentrations (mmol/kg wet weight).
| Metabolites | HC (n=25) | MCDs (n=29) | GMH (n=10) | FCD (n=10) | PMG (n=9) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NACS | Lesion | NACS | Lesion | NACS | Lesion | NACS | Lesion | |||||
| Ins | 4.82±0.49 | 4.77±0.85 | 5.67±1.53*† | 4.86±1.05 | 5.19±1.77 | 4.91±0.95 | 6.06±1.56*† | 4.55±0.39 | 5.77±1.22† | |||
| NAA | 7.47±0.50 | 7.40±1.05 | 6.79±1.00*† | 7.09±1.12 | 6.38±1.14*‡ | 7.65±0.83 | 6.81±0.91*† | 7.51±1.17 | 7.22±0.83 | |||
| Cho | 1.38±0.10 | 1.52±0.29* | 1.63±0.39* | 1.48±0.27 | 1.52±0.32 | 1.61±0.29 | 1.89±0.50† | 1.45±0.23 | 1.51±0.19 | |||
| Cr | 5.57±0.46 | 5.81±0.87 | 6.11±0.94* | 5.75±1.22 | 5.57±0.91 | 5.92±0.72 | 6.25±0.86† | 5.80±0.53 | 6.56±0.86*† | |||
| Glx | 10.15±1.19 | 10.20±2.59 | 10.36±1.67 | 10.93±3.35 | 10.22±1.48 | 9.86±2.54 | 9.96±1.85 | 9.79±1.52 | 10.95±1.70† | |||
Data are expressed as the group mean ± standard deviation. *, P<0.05 in comparison with the HC; †, P<0.05 in pairwise comparison with the corresponding NACS; ‡, P<0.05 in comparison between GMH_lesion and PMG_lesion. HC, healthy controls; MCDs, malformations of cortical development; NACS, normal-appearing contralateral side; GMH, gray matter heterotopia; FCD, focal cortical dysplasia; PMG, polymicrogyria; Ins, myoinositol; NAA, N-acetyl aspartate; Cho, choline; Cr, creatine; Glx, glutamate + glutamine.