Table 3.
Multivariable competing risk model for breast cancer metastasis and breast cancer death versus competing events according to SNP-based prognostic groups and patients’ baseline characteristics.
BC metastasis and BC death | Competing events | |||
---|---|---|---|---|
N = 878, events = 73 | N = 878, events = 58 | |||
Variable | sHR (95% CI) | P value | sHR (95% CI) | P value |
SNP-based groups | ||||
0 high-risk SNP | 1 | 1 | ||
1 high-risk SNP | 2.55 (1.00–6.45) | 0.048 | 1.18 (0.55–2.55) | 0.671 |
>1 high-risk SNP | 3.48 (1.33–9.13) | 0.011 | 1.06 (0.44–2.58) | 0.890 |
Tumor size | ||||
pT1 | 1 | 1 | ||
pT2 | 1.90 (1.13–3.20) | 0.016 | 1.29 (0.71–2.34) | 0.402 |
pT3–4 | 3.56 (1.79–7.10) | <0.001 | 1.28 (0.44–3.73) | 0.652 |
Nodal status | ||||
pN0 | 1 | 1 | ||
pN+ | 3.15 (1.62–6.13) | <0.001 | 1.16 (0.62–2.17) | 0.647 |
(Neo)adjuvant chemotherapy | ||||
No | 1 | 1 | ||
Yes | 1.22 (0.52–2.84) | 0.652 | 1.16 (0.62–2.17) | 0.990 |
Age at diagnosis | 0.99 (0.97–1.03) | 0.940 | 1.03 (1.00–1.07) | 0.037 |
Study cohort | ||||
GIM4 | 1 | 1 | ||
GIM5 | 0.95 (0.58–1.56) | 0.835 | 0.37 (0.18–0.78) | 0.009 |
Abbreviation: BC, breast cancer.