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. 2023 Dec 1;14:1285943. doi: 10.3389/fimmu.2023.1285943

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Copyright © 2023 Bernardo, Solana, Sánchez, Torres, Reyes-Cruz, Carrillo and Moreno

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokine production after splenocyte stimulation with αCD3/αCD28. At W9, after the Glucantime^® treatment, splenocytes were stimulated with αCD3/αCD28 for 24 h. The supernatants were collected and IFN-γ (A), IL-2 (B), TNF (C), IL-17 (D), IL-6 (E), IL-10 (F) and IL-4 (G) cytokines secreted to the medium analysed using the CBA BD Th1/Th2/Th17 Kit. The Mann-Whitney test was used to analyse the differences between groups (p<0.05). Significant differences within groups at W6 and W9 are marked with a * sign; a ⁺ sign indicates significant differences compared to the control group for the same week; a ^x sign indicates differences between immunosuppressed groups at W6 or W9 (p<0.05) **p<0.01; ⁺⁺p<0.01; ^xxp<0.01.