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. 2023 Dec 1;14:1275612. doi: 10.3389/fendo.2023.1275612

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Copyright © 2023 Lu, Liu, Zhao, Bie, Liu, Xie, Wang, Zhu, Xiong, Qin, Yang, Chen and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the gene characteristics, healing-related biological pathways, and significantly differentially expressed genes between the DFU-Healer and DFU-Non-Healer groups. (A) Bubble plot illustrating the significant differences in immune and inflammation related KEGG pathway between DFU-Healer and DFU-Non-Healer endothelial cells. (B) The significantly enriched GESA plot(FDR<0.05) based on the KEGG pathways in (A). (C) The Venn diagram showcases the intersection of 46 immune and inflammation related pathways enriched with significantly differentially expressed genes in DFU-Healer and DFU-Non Healer endothelial cells, as well as the 43 pathways enriched with immune and inflammation related target genes. The diagram reveals a total of 43 common pathways (left), where the DFU-Healer and DFU-Non-Healer endothelial cells share 46 healing-related genes and 47 target genes. The Venn diagram displays 5 genes that are common to both groups (right): CCND1, ENO1, HIF1α, MMP2, and SERPINE1. (D) The Protein-Protein Interaction Network analysis demonstrates the interactions among these 5 common genes in (C). (E) Dot plots illustrates the differential expression (p<0.05) of CCND1, ENO1, HIF1α, MMP2, and SERPINE1 between the DFU-Healer and DFU-Non Healer groups. (F) The immunofluorescence validation of protein expression, with CD31 labeled in red, CCND1, ENO1, HIF1α, and SERPINE1 labeled in green, and DAPI staining in blue. Scale bars are 200 μm.