Fig. 1.

Classification chart for m6A regulators. The m6A modification is a dynamic and reversible epigenetic modification regulated by the “author” and “eraser” and is mainly catalyzed by the m6A methyltransferase complex, which includes the major components METTL3/METTL14/WTAP and other regulatory proteins (RBM15/15B, ZC3H13, HAKA, and VIRMA). In addition, METTL16, METTL5, METTL4, ZCCHC4, and PCIF1 are methyltransferases that directly catalyze m6A modifications in RNA molecules. The eraser consists mainly of FTO, ALKBH3, and ALKBH5. The “readers” are binding proteins that recognize the m6A modification and determine the fate of target RNAs, and they mainly include members of the YTH domain-containing family, the IGF2BP family, the HNRNP family, eIF3, PRRC2A, and FMRP