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. Author manuscript; available in PMC: 2024 Jul 4.
Published in final edited form as: Expert Opin Ther Targets. 2023 Jul 4;27(6):419–431. doi: 10.1080/14728222.2023.2230361

Figure 4. The topological position of signature mutations emerged in the 2022 outbreak in MPXV F8L.

Figure 4.

– Panel a depicts the signature mutation W411L in the poxvirus-specific ‘insert 2’ (rendered as forestgreen ribbons). The relative position of the 3’- 5’ exonuclease site (D268) is also a reference. Panel b shows that the 2022 MPXV signature mutation L108F (ball-and-stick) within the N-terminal domain (represented as orange ribbons) stacks against the template base as seen in the cryo-EM structure of MPXV DNA replication holoenzyme (PDB entry 8HG1).