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. 2023 Dec 13;19:17448069231222406. doi: 10.1177/17448069231222406

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Pharmacological Manipulation of AMPA Subunits Reduce Mechanical Hyperalgesic Priming. Male rats were injected i.pl. with vehicle or Complete Freund’s Adjuvant (CFA, 50% in 50 μL saline). Over the next 4 days, rats were injected daily with vehicle or NBQX (AMPA GluR1 antagonist, 200 nmol/50 μL, i.pl., (a and b), or control peptide (Con) or TAT-GluA2-3g (TAT, GluR2 internalization inhibitor, 50 nmol/50 μL, i.pl., (c and d). Rats were tested for paw withdrawal threshold (PWT, g) on Day 5, then injected with PGE₂ (100 ng in 50 μL saline, i.pl.), and again tested for PWT 0.25, 0.5, 2, and 4 h. n = 24 rats/treatment, triplicate readings per time point; compared to Veh/PGE₂ (a, *p = .0167, ****p < .0001, c, **p = .0028, ****p < .0001), two-way ANOVA with Sidak’s multiple Comparisons test.