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. 2023 Dec 13;19:17448069231222406. doi: 10.1177/17448069231222406

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Mechanism of AMPA Modulation in Persistent Pain. Inflammation drives AKAP association with AMAP GluR1/2 heteromer. AKAP Scaffolds PKC phosphorylation of GluR2 (causing internalization of the subunit) and PKA phosphorylation of GluR1 (causing subunit tetramerization and glutamate-dependent Ca⁺² influx.