Fig. 3.

Number, proportion, identity, and characteristics of common AS events in PAE and OMD. (A) Five AS event types (SE, MXE, A3SS, A5SS, and RI) assessed. (B–G) Circos plots show chromosomal distribution of significant AS events in B cells (B and E), T cells (C and F) and monocytes (D and G), in PAE (B–D) and OMD (E–G). Outermost circle blocks represent 21 mouse chromosomes. Length of these blocks and density of their monochrome fill are proportional to relative chromosomal length and relative density of significant AS events in that chromosome respectively. Each inner concentric circle represents an AS type. Black and red dots represent significant AS events with +Δpsi and −Δpsi respectively. (H–J) Venn diagrams show number and proportion of unique and common significant AS events in PAE and OMD, in comparison to their respective controls, in B cells (H), T cells (I), and monocytes (J). (K–N) Volcano plots show distribution of significant AS events (green), among non-significant AS events (gray), of A3SS (K and M) and SE (L and N) AS types in T cells in PAE (K and L) and OMD (M and N). Arrows indicate distribution of 13 significant AS events common to PAE and OMD in T cells. (O–T) Volcano plots show distribution of significant AS events (red), among non-significant AS events (gray), of A3SS (O and R), A5SS (P and S), and SE (Q and T) AS types in B cells in PAE (O–Q) and OMD (R–T). Arrows indicate distribution of 16 significant AS events common to PAE and OMD in B cells. AS events with a Δpsi > 5% and FDR < 5% were considered significant.