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. 2023 Sep 25;10(12):2255–2265. doi: 10.1002/acn3.51909

Figure 2.

Figure 2

low‐BP is associated with unfavorable functional outcome and increased sNfL level. (A) Patients achieving BP target ≤ 160/90 mmHg have worse functional outcome at 90‐day follow‐up (low‐BP ≤ 160/90 mmHg: median [IQR] mRS: 4 [3–6] vs. high BP > 190/90 mmHg: median [IQR] mRS: 2 [0–5], p = 0.002). (B) low‐BP is associated with worse health‐related quality of life as assessed by EQ‐5D index value 90 days after MT (BP ≤ 160/90 mmHg: mean EQ‐5D index value: 0.045 ± 0.28 vs. high BP > 160/90 mmHg mean EQ‐5D index value: 0.63 ± 0.31, p = 0.009). (C) low‐BP is associated with increased sNfL level (BP ≤ 160/90 mmHg median [IQR] sNfL: 239.7 pg/mL [168.4–303.4] vs. high BP > 160/90 mmHg median [IQR] sNfL: 118.8 pg/mL [52.5–220.5], p = 0.026). (D) Receiver operating characteristic (ROC) curve for identification of patients with MAP drops < 60 mmHg by sNfL levels revealed an Area under the ROC(AUC) of 0.68 (95%CI: 0.56–0.78. p = 0.007). The optimal cut‐off for discrimination of patients with MAP drops below 60 mmHg by sNfL was sNfL > 132.4 pg/mL. BP, blood pressure; EQ‐5D, European quality of life index version 5D; sNfL, serum neurofilament light chain.