Extended Data Figure 4.

(a) IHC analysis of KPC tumors from Fig. 4. Tumors stained for CC3. Quantification of IHC images was compared between Vehicle, RMC-7977 (1 week + 4 hour) and RMC-7977 (1 week + 24 hour). Quantification was based on 10–15 fields of view (light shade), averaged per tumor (dark shade) and means were compared by Student’s unpaired t-test (*, p<0.05). Error bars indicate s.d. (b) Tolerability of RMC-7977 in KPC mice as assessed by percent animal body weight change from baseline over the course of treatment.