Figure 3: Gene expression differences between K13^580Y and K13^C580 parasites.

A. Kelch13 gene expression was observed to be downregulated in the K13^580Y parasite population compared to the K13^C580 (BH-adjusted p-value<0.01 and log2FC=1.5). PfKelch13 gene expression across the parasite stages in each line, shows PfKelch13 gene to be highly expressed in the K13^C580 across all the stages compared to K13^580Y. B. Volcano plot showing DEGs in the untreated K13^580Y compared to untreated K13^C580 on different parasite stages. Each red dot denotes genes differentially expressed between the K13^C580 and the K13^580Y (such as GARP and MAHRP1 which are upregulated in K13^580Y rings compared to K13^C580 rings).