Figure 6: Gene expression differences between DHA treated K13^580Y and K13^C580 parasites.

A. PfGARP was observed to be highly expressed in the K13^580Y parasite population compared to the K13^C580 parasite population (BH-adjusted p-value<0.01 and log2FC=3.8). Stratifying the PfGARP expression across the parasite stages in each strain shows PfGARP to be highly expressed in K13^580Y across all the stages compared to K13^C580. B. Volcano plot showing DEGs in K13^580Y treated with DHA versus K13^C580 treated with DHA at 3 different timepoints. Each red dot denotes genes passing p-value and fold change difference (BH-adjusted p-value<0.001, average log2 fold-change>0.3) thresholds. The dots on the right are the upregulated genes induced due to DHA exposure. The red dots on the left represent the downregulated genes passing the p-value and fold change difference thresholds between the DHA treated parasite and the DMSO treated parasite control (BH-adjusted p-value<0.001, average log2 fold-change<−0.3).