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[Preprint]. 2023 Dec 6:rs.3.rs-3694879. [Version 1] doi: 10.21203/rs.3.rs-3694879/v1

Figure 1. Neoplastic-immune hybrids detected in primary UMs identified using cyCIF.

Figure 1

Hybrid cells identified by their co-expression of pan-leukocyte immune protein, CD45 (orange), and one or more melanocytic proteins [HTR2B (green), MITF (light pink), MLANA (magenta), Tyrosinase (red), or GP100 (yellow)]. Class 2 hybrid shows expression of HTR2B and decreased expression of tyrosinase compared to class 1 hybrid cells. Hybrid cells shown in image insets were identified in the primary tumor. H&E whole globe images for both patient samples with marked area of analyses.