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[Preprint]. 2023 Dec 6:rs.3.rs-3692289. [Version 1] doi: 10.21203/rs.3.rs-3692289/v1

Figure 3.

Figure 3

Kaplan Meier survival curves from left to right based on (a) established gene-expression endotype (A in red vs. B in blue), (2) latent profile phenotype (‘inflamed in orange and ‘uninflamed’ in brown), and (3) an integrated subclass assignment scheme that considered both the endotype and phenotype assignment among individual patients. The latter included all four possible combinations including (i) endotype A/inflamed (deep purple), (ii) endotype B/inflamed (deep plum), (iii) endotype A/uninflamed (light magenta), (iv) endotype B/uninflamed (orange). Patients with endotype A had a higher relative risk of 28-day mortality compared to endotype B (RR 3.7 (95% CI: 1.5, 8.7), p=0.003). Patients with an ‘inflamed’ phenotype had a higher relative risk of 28-day mortality compared to those with an ‘uninflamed’ phenotype (RR 4.5 (95% CI: 1.9, 10.6), p<0.001). Patients assigned as both endotype B and ‘uninflamed’ had the lowest mortality risk. Compared to this group, patients classified as endotype A & inflamed had a higher relative risk of mortality (RR 12.5 (95%CI: 3.8, 41.2), p <0.001). Patients classified as endotype B & ‘inflamed’ had a relative risk of mortality of 4.8 (95% CI: 1.1, 20.1, p=0.032). Patients classified as endotype A & uninflamed had a relative risk of mortality of 3.6 (95%CI: 1.2, 11.1), p=0.024. There were no statistically significant differences between the latter two groups.