Table 2.
Results of tests for interaction between pediatric septic shock latent profile phenotypes and common sepsis therapies on clinical outcomes.
| Inflamed | Uninflamed | P value | |||
|---|---|---|---|---|---|
| ≥ 100 ml/kg (n=118) | <100 ml/kg (n=77) | ≥ 100 ml/kg (n=506) | <100 ml/kg (n=367) | ||
| 7-day mortality | 35 (29.7%) | 14 (18.2%) | 25 (4.9%) | 20 (5.5%) | 0.081 |
| 28-day mortality | 45 (38.1%) | 19 (24.7%) | 46 (9.1%) | 29 (7.9%) | 0.169 |
| Complicated course | 84 (71.2%) | 37 (48.1%) | 161 (31.8%) | 72 (19.6%) | 0.280 |
| Inflamed | Uninflamed | P value | |||
| ≥ 2ABMs (n=177) | < 2 ABMs (n=20) | ≥ 2ABMs (n=793) | < 2 ABMs (n=81) | ||
| 7-day mortality | 47 (26.6%) | 4 (20.0%) | 40 (5.1%) | 6 (7.4%) | 0.316 |
| 28-day mortality | 61 (34.5%) | 5 (25.0%) | 67 (8.5%) | 9 (11.1%) | 0.269 |
| Complicated course | 116 (65.5%) | 7 (35.0%) | 211 (26.6%) | 23 (28.4%) | 0.021* |
| Inflamed | Uninflamed | P value | |||
| ≥ 2 VA (n=112) | <2 VA (n=85) | ≥ 2 VA (n=344) | <2 VA (n=530) | ||
| 7-day mortality | 36 (32.2%) | 15 (17.7%) | 26 (7.6%) | 20 (3.8%) | 0.908 |
| 28-day mortality | 44 (39.3%) | 22 (25.9%) | 37 (10.8%) | 39 (7.4%) | 0.844 |
| Complicated course | 80 (71.4%) | 43 (50.6%) | 119 (34.6%) | 115 (21.7%) | 0.622 |
| Inflamed | Uninflamed | P value | |||
| Steroids (n=135) | No Steroids (n=62) | Steroids (n=466) | No steroids (n=408) | ||
| 7-day mortality | 40 (29.6%) | 11 (17.7%) | 34 (7.3%) | 12 (2.9%) | 0.532 |
| 28-day mortality | 52 (38.5%) | 14 (22.6%) | 57 (12.2%) | 19 (4.7%) | 0.454 |
| Complicated course | 95 (70.4%) | 28 (45.2%) | 147 (31.6%) | 87 (21.3%) | 0.101 |
| Inflamed | Uninflamed | P value | |||
| Intubated (n=88) | Not intubated (n=109) | Intubated (n=352) | Not intubated (n=522) | ||
| 7-day mortality | 31 (35.2%) | 20 (18.4%) | 28 (7.9%) | 18 (3.5%) | 0.847 |
| 28-day mortality | 42 (47.7%) | 24 (22.1%) | 46 (13.1%) | 30 (5.8%) | 0.674 |
| Complicated course | 71 (80.7%) | 52 (47.7%) | 136 (38.6%) | 98 (18.8%) | 0.244 |
| Inflamed | Uninflamed | P value | |||
| CRRT (n=42) | No CRRT (n=155) | CRRT (n=21) | No CRRT (n=853) | ||
| 7-day mortality | 15 (35.7%) | 36 (23.3%) | 1 (4.8%) | 45 (5.3%) | 0.461 |
| 28-day mortality | 22 (52.4%) | 44 (28.4%) | 8 (38.1%) | 68 (8.0%) | 0.155 |
| Complicated course | 34 (80.9%) | 89 (57.4%) | 14 (66.7%) | 220 (25.8%) | 0.424 |
ABM: Anti-microbials.
VA: Vasoactive agents.
Day 1 Intubation.
Day 1 CRRT initiation.
P value for interaction between phenotype and intervention on clinical outcome tested based on logistic regression including age and PRISM III score as covariates