Table 1:
Comparison of SNPs significant in Gelernter et al. (1) that are also reported in Kranzler et al. (5).
| P-values | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | rsID | Gelernter Maxalc. META | Gelernter Maxalc. EUR | Gelernter Maxalc. AA | Kranzler AUDIT-C. METAa | Kranzler AUDIT-C. EUR | Kranzler AUDIT-C. AA | Kranzler AUD. META | Kranzler AUD. EUR | Kranzler AUD. AA |
| ADH1B | rs1229984 | 1.1E-49 | 4.9E-47 | 3.6E-133 | 4.8E-102 | 1.3E-19 | 4.7E-85 | 4.5E-74 | 4.2E-05 | |
| ADH1B | rs2066702 | 2.3E-12 | 6.4E-15 | 1.3E-03 | 4.7E-24 | |||||
| CRHR1b | rs61667602; rs77804065 | 1.0E-13 | 1.5E-12 | |||||||
| FGF14 | rs1360983 | 9.9E-09 | ||||||||
| XPO7b | rs2291317; rs7821592 | 2.5E-08 | 3.6E-08 | |||||||
| RNU6–53P | rs1577857 | 4.2E-08 | 4.2E-08 | 2.2E-05 | 8.3E-09 | 2.6E-01 | 3.2E−9 | 3.2E−7 | 8.7E−3 | |
| LOC105376602 | rs7931459 | 4.6E-08 | ||||||||
| GCKR | 5.8E-06 | 2.0E−16 | 1.7E−16 | 0.11 | 2.3E−13 | 1.4E−16 | 0.68 | |||
| KLB | 5.5E-06 | 3.1E−9 | 3.5E−9 | NA | ||||||
Data assembled from the two studies, both of which were drawn from the MVP; the degree of overlap was not reported in either.
a
Kranzler meta-analysis included additional populations.
b
Different top SNPs in EUR vs. meta-analysis.