Table 3.
Prognostic factors associated with kidney survival
| Parameter | Unadjusted Survival Analysis | Multivariable Analysis |
|---|---|---|
| Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |
| Age, yr | 1.02 (0.98 to 1.06) | |
| Male | 1.35 (0.58 to 3.12) | |
| 24-h urine protein, g/24 h | 1.02 (0.96 to 1.09) | |
| Urine red blood cells, per µl | 1.00 (1.00 to 1.00) | |
| Serum albumin, g/dl | 0.52 (0.24 to 1.12) | |
| Serum creatinine at biopsy, mg/dla,b | 1.55 (1.27 to 1.89) | 1.47 (1.15 to 1.87)c |
| Hemoglobin, g/La,b | 0.97 (0.95 to 0.99) | |
| Detection of clone | 0.62 (0.21 to 1.87) | |
| Percentage of global glomerulosclerosis, %a,b | 1.06 (1.02 to 1.10) | 1.05 (1.01 to 1.10)d |
| Percentage of crescents, %a,b | 1.04 (1.00 to 1.07) | |
| Bortezomib-based chemotherapyb | 0.52 (0.19 to 1.41) | |
| Urinary C3a/creatinine, ng/mg | 1.00 (1.00 to 1.00) | |
| Urinary C5a/creatinine, ng/mg | 1.00 (1.00 to 1.00) | |
| Urinary sC5b-9/creatinine, g/mga,b | 1.00 (1.00 to 1.00) | |
| Urinary C4d/creatinine, µg/mga,b | 1.39 (1.11 to 1.75) | 1.36 (1.00 to 1.83)e |
| Urinary C1q/creatinine, ng/mg | 1.04 (0.93 to 1.16) | |
| Urinary MBL/creatinine, ng/mg | 1.01 (1.00 to 1.02) | |
| Urinary Bb/creatinine, µg/mga,b | 1.06 (1.01 to 1.11) | |
| Plasma C3a, ng/ml | 1.00 (1.00 to 1.00) | |
| Plasma C5a, ng/ml | 1.00 (1.00 to 1.00) | |
| Plasma sC5b-9, ng/ml | 1.00 (1.00 to 1.00) | |
| Plasma C4d, µg/ml | 1.07 (0.98 to 1.16) | |
| Plasma C1q, ng/ml | 1.00 (1.00 to 1.00) | |
| Plasma MBL, ng/ml | 1.00 (1.00 to 1.00) | |
| Plasma Bb, µg/ml | 1.19 (0.69 to 2.06) | |
| Intensity of global C3ca,b | 1.07 (1.00 to 1.13) | |
| Intensity of global C5b-9×100 | 1.03 (0.73 to 1.46) | |
| Intensity of global C4d×100 | 1.15 (0.94 to 1.40) | |
| Intensity of global C1q | 1.06 (0.97 to 1.15) | |
| Intensity of global MBL | 0.63 (0.18 to 2.18) | |
| Intensity of global Bb | 1.09 (0.80 to 1.49) |
CI, confidence interval; sC5b-9, soluble C5b-9; MBL, mannose-binding lectin.
a
In unadjusted survival analysis, P < 0.05.
b
Variables were incorporated into multivariable Cox regression.
c
In multivariable analysis, P = 0.002.
d
In multivariable analysis, P = 0.01.
e
In multivariable analysis, P = 0.05.