TABLE 2.
Overall | Post-hospitalization Neuro-PASC (PNP) |
Non-hospitalized Neuro-PASC (NNP) |
p-Value | |
---|---|---|---|---|
n | 600 | 100 | 500 | |
Any pre-existing comorbidity n (%) | ||||
Depression/anxiety | 209 (34.8) | 9 (9) | 200 (40) | <0.0001 |
Hypertension | 116 (19.3) | 39 (39) | 77 (15.4) | <0.0001 |
Dyslipidemia | 86 (14.3) | 22 (22) | 64 (12.8) | 0.03 |
Autoimmune diseasea | 70 (11.6) | 14 (14) | 56 (11.2) | 0.4 |
Headache | 46 (7.7) | 4 (4) | 42 (8.4) | 0.15 |
Type 2 Diabetes | 42 (7) | 21 (21) | 21 (4.2) | <0.0001 |
Cancer | 41 (6.8) | 11 (11) | 30 (6) | 0.08 |
Other Endocrine disordersb | 40 (6.6) | 9 (9) | 31 (6.2) | 0.28 |
Insomnia | 38 (6.3) | 2 (2) | 36 (7.2) | 0.07 |
Lung Diseasec | 37 (6.2) | 16 (16) | 21 (4.2) | <0.0001 |
Gastrointestinal diseased | 29 (4.8) | 1 (1) | 28 (5.6) | 0.07 |
Neuropsychiatric diseasee | 24 (4) | 5 (5) | 19 (3.8) | 0.58 |
Cardiovascular diseasef | 21 (3.5) | 10 (10) | 11 (2.2) | 0.0008 |
Traumatic brain injury | 19 (3.2) | 4 (4) | 15 (3) | 0.54 |
Peripheral vascular disease | 12 (2) | 5 (5) | 7 (1.4) | 0.03 |
Dysautonomia | 8 (1.3) | 2 (2) | 6 (1.2) | 0.63 |
Chronic kidney disease | 7 (1.2) | 2 (2) | 5 (1.0) | 0.33 |
Cerebrovascular disease | 6 (1) | 4 (4) | 2 (0.4) | 0.008 |
Neuromuscular diseaseg | 6 (1) | 4 (4) | 0 (0) | 0.005 |
Organ transplant | 1 (0.1) | 1 (1) | 0 (0) | 0.17 |
Otherh | 70 (11.6) | 17 (17) | 53 (10.6) | 0.09 |
PNP: Hashimoto thyroiditis (5), rheumatoid arthritis (3), Multiple Sclerosis (2), connective tissue disease (2), systemic lupus erythematosus (2), diabetes type 1 (1), Bechet’s (1), ulcerative colitis (1), giant cell arteritis (1), psoriatic arthritis (1). NNP: Hashimoto thyroiditis (15), rheumatoid arthritis (11), Sjogren (4), Crohn’s disease (3), eczema (3) multiple sclerosis (2), systemic lupus erythematosus (2), celiac disease (3), psoriasis (2), Graves’ disease (2), ulcerative colitis (1), sarcoidosis (1), Henoch Schonlein purpura (1), diffuse scleroderma (1), multifocal motor neuropathy (1), eosinophilic esophagitis (1), Raynaud’s (1).
PNP: Hypothyroidism (6), adrenal insufficiency (2), PCOS (1). NNP: Hypothyroidism (18), PCOS (7), osteoporosis (3), thyroid cysts (1), primary hyperparathyroidism (1), adrenal insufficiency (1).
PNP: COPD/emphysema (4), interstitial lung disease (6), asthma (4), obstructive sleep apnea (2). NNP: Interstitial lung disease (20), asthma (19), obstructive sleep apnea (4), COPD/emphysema (1).
PNP: Primary sclerosing cholangitis (1). NNP: GERD (18), inflammatory bowel disease (6), polycystic liver disease (1), fatty liver (1), duodenal atresia (1), colitis (1).
PNP: Prior alcohol use disorder (2), fibromyalgia (1), HSV meningoencephalitis (1), congenital hydrocephalus (1). NNP: Fibromyalgia (6), benign paroxysmal positional vertigo (BPPV) (2), attention deficit hyperactivity disorder (2), essential tremor (1), tinnitus (1), Tourette’s syndrome (1), narcolepsy (1), bipolar disease (1), spinal stenosis (1), neurogenic bladder (1), autonomic dysreflexia (1), Chiari malformation type 1 (1).
PNP: Congestive heart failure (5), coronary artery disease (4), atrial fibrillation (1), cardiomyopathy (1). NNP: coronary artery disease (6), arrhythmia other than atrial fibrillation (2), atrial fibrillation (1), mitral valve prolapse (1), myocarditis (1).
PNP: Muscular dystrophy (1), cervical compression (1), lumbar spinal stenosis (1). NNP: None.
PNP: Cigarette smoking (14), essential thrombocytopenia (1), MGUS (1), myelodysplastic syndrome (1). NNP: Osteoarthritis (7), seasonal allergies (7), postural orthostatic tachycardia syndrome (POTS) (5), anemia (5), syphilis (3), gout (3), osteopenia (3), endometriosis (2), thrombocytopenia (2), glaucoma (2), Ehlers Danlos (1), infertility (1), urticaria (1), deep venous thrombosis (1), sinusitis (1), thrombocytopenia (1), nephrolithiasis (1), costochondritis (1), pernicious anemia (1), infectious mononucleosis (1), shingles (1), erectile dysfunction (1), protein S deficiency (1), sickle cell trait (1).