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. 2023 Dec 15;14:8221. doi: 10.1038/s41467-023-44016-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Scatter plot showing the relationship between 5-HT_2A receptor Gq-efficacy (E_MAX values) and head-twitch response (HTR) magnitude (maximum counts per minute induced by the compound) for 14 members of the 25N series. Spearman’s rank correlation coefficient R_s is shown. The regression line generated by fitting the data using non-linear regression is included as a visual aid. B Scatter plot showing the relationship between 5-HT_2A receptor β-arrestin2 recruitment efficacy (E_MAX values) and HTR magnitude for 14 members of the 25N series. C Scatter plot showing the relationship between 5-HT_2A receptor Gq-efficacy (E_MAX values) and HTR magnitude for 24 phenethylamine psychedelics. To illustrate the non-linear nature of the relationship, the regression line generated by fitting the data using non-linear regression is shown. D Scatter plot showing the relationship between 5-HT_2A receptor β-arrestin2 recruitment efficacy (E_MAX values) and HTR magnitude for 24 phenethylamine psychedelics. Source data are provided as a Source Data file.