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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Ann Surg. 2023 Jun 16;278(6):e1289–e1298. doi: 10.1097/SLA.0000000000005940

Figure 5. Mechanical and pharmacologic modulation of neutrophils mitigates HO.

Figure 5.

(A) MicroCT analysis of tenotomy site 9 weeks after burn/tenotomy in mobilized versus immobilized mice following daily treatment of either sterile water (control) or hydroxychloroquine (HCQ). n=5–7/group. (B) Quantification of neutrophils (CD45+CD11b+Ly6G+ cells) as assessed by flow cytometry at Day 7 post-injury in control BT, HCQ treated BT, and immobilized BT groups. n=3–4. (C) MicroCT analysis of tenotomy site 9 weeks after burn/tenotomy following 2 weeks daily injection of sterile water (control), ODN-2088 or HCQ. n=6–9. (* = p<0.05, ** = p<0.01, ****p<0.001). Stars indicate a significant decrease as compared to the control BT.