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. 2023 Oct 22;10(35):2305472. doi: 10.1002/advs.202305472

Figure 1.

Figure 1

Maternal HFD feeding during lactation increases the susceptibility to HFD‐induced obesity in the male adult offspring mice, but not in females. A–D) The change of body weight (A and B) and body fat mass （C and D） in adult male (M) and female (F) offspring mice raised by mothers fed a high‐fat diet (HFD) or a control low‐fat diet (CON) during lactation in response to an 11‐week HFD exposure (male: n = 8; female: n = 9). (E and F) The change of maternal body weight and energy intake in mothers fed an HFD (n = 7) or a CON (n = 8). G,H) The effect of maternal HFD on the change of (G) total litter mass and H) average litter mass (n = 7–8). I,J) The effect of maternal HFD on dissected subcutaneous, visceral, and total fat mass of male and female pups on postnatal day 15 (n = 7) and day 21 (n = 6). Values are represented as mean ± SEM. Statistical tests include two‐way ANOVA (A–H) and unpaired Student's t‐test (I, J), and differences with p < 0.05 were considered statistically significant. *p < 0.05, **p < 0.01.