Figure 2.

Fold-rises by vaccine group and dose. Depiction of titer fold-rises from baseline (visit 1, prior to the first dose), shown by randomization group (SD-QIV and HD-TIV) for each antigen and each follow-up visit. The estimated GMFR and 95% confidence intervals are depicted in black. Visit 2 titers are measured at a target window of 28–42 d following the first dose (prior to the second dose), visit 3 titers are measured at a target window of 28–42 d following the second dose, and visit 4 titers are measured at a target window of 124–236 d following the visit 3. Furthermore, B/Yamagata was not included in HD-TIV. Abbreviations: GMFR, geometric mean fold-rise; HD-TIV, high-dose trivalent; SD-QIV, standard-dose quadrivalent.