Table 3.
Uni- and Multivariable Regression Results Comorbidities Versus Presence of Plaque
| Any Coronary Plaque | Univariable | Model 1 | Model 2 | Model 3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95%CI | P Value | OR | 95% CI | P Value | OR | 95% CI | P Value | |
| PCAT density (per 10 HU) | 1.30 | 1.13–1.50 | <.001 | 1.26 | 1.09–1.47 | .002 | 1.38 | 1.18–1.62 | <.001 | 1.44 | 1.22–1.70 | <.001 |
| Age, y | … | … | … | … | … | … | 1.10 | 1.07–1.13 | <.001 | |||
| Sex (male) | … | … | … | … | … | … | 2.18 | 1.34–3.56 | .002 | |||
| Race | ||||||||||||
| White | … | … | … | … | … | … | ref. | … | ||||
| Black or African American | … | … | … | … | … | … | 0.69 | .46–1.03 | .066 | |||
| Asian | … | … | … | … | … | … | 1.61 | .39–6.72 | .513 | |||
| Other | … | … | … | … | … | … | 0.98 | .56–1.70 | .941 | |||
| ASCVD, % | … | … | 1.16 | 1.10–1.22 | <.001 | 1.14 | 1.08–1.21 | <.001 | … | … | ||
| BMI, kg/m2 | … | … | 1.01 | .97–1.04 | .619 | 1.01 | .97–1.04 | .772 | 1.02 | .98–1.06 | .272 | |
| Substance abuse | … | … | 1.26 | .93–1.72 | .134 | 1.20 | .87–1.65 | .265 | 1.23 | .87–1.72 | .237 | |
| Smoking (current) | … | … | … | … | … | … | 1.27 | .84–1.92 | .259 | |||
| MCP-1, pg/mL | … | … | … | … | 1.09 | .99–1.20 | .066 | 1.06 | .96–1.17 | .259 | ||
| IL-6, pg/mL | … | … | … | … | 1.05 | 1.00–1.11 | .048 | 1.06 | 1.00–1.12 | .041 | ||
| LpPLA2, ng/mL | … | … | … | … | 1.19 | 1.10–1.28 | <.001 | 1.15 | 1.06–1.25 | .001 | ||
| oxLDL, mU/L | … | … | … | … | 1.09 | .99–1.20 | .090 | 1.13 | 1.02–1.25 | .021 | ||
| hsCRPm mg/L | … | … | … | … | 1.02 | .98–1.07 | .342 | 1.03 | .99–1.08 | .179 | ||
P values were obtained with logistic regression modelling.
Abbreviations: ASCVD, atherosclerotic cardiovascular disease; BMI, body mass index; CI, confidence interval; hsCRP, high-sensitivity C-reactive protein; HU, Hounsfield unit; IL-6, interleukin 6; LpPLA2, lipoprotein-associated phospholipase A2; MCP-1, monocyte chemoattractant protein 1; OR, odds ratio; oxLDL, oxidized low-density lipoprotein; PCAT, pericoronary adipose tissue.