Table 1.

Behavioral tasks and experimental manipulations. Cohort 1 (n = 12) consisted of female Long-Evans rats, half of which were hippocampal-lesioned. This cohort completed the delayed alternation (DA) task. Cohorts 2, 3 and 4 consisted of equal numbers of SHR and WKY rats of both sexes. Cohort 2 (n = 24) and Cohort 4 (n = 12) completed the light-dark box (LDB) test. Cohort 2 also completed the DA task. Cohort 3 (n = 22) completed the time duration discrimination (TDD) task. All cohorts were food deprived for ∼6 weeks and sacrificed after behavioral testing. Cohorts 2, 3 and 4 underwent brain extraction and cytokine analysis via a Luminex immunoassay.

	DA	TDD	LDB	Luminex
COHORT 1	✓
COHORT 2	✓		✓	✓
COHORT 3		✓		✓
COHORT 4			✓	✓