Table 3.

Identified metabolites in arginine and proline metabolism pathway via combined POS and NEG model analysis

Metabolites	variation trend	MS2 score	MEAN	log2(fc)
5-Aminopentanoic acid	up	1.000	12.911	0.172
L-Arginine	up	0.977	0.579	2.280
L-Glutamic acid	up	0.995	39.837	0.706
N-Acetyl-L-alanine	up	0.998	2.531	0.480
Pyrrole-2-carboxylic acid	up	0.998	1.618	0.864
4-Guanidinobutanoic acid	down	0.983	82.363	-1.949
Argininosuccinic acid	down	0.749	0.330	-0.924
Citrulline	down	0.966	5.967	-0.890
Creatine	down	0.990	140.793	-9.632
Creatinine	down	0.951	27.266	-0.632
Hydroxyproline	down	0.998	7.080	-2.686
L-Aspartic acid	down	0.871	0.050	-0.464
L-Proline	down	1.000	59.569	-0.818
N-Acetylputrescine	down	0.945	11.949	-7.518
Ornithine	down	0.999	1.840	-0.865
Phosphocreatine	down	0.644	0.077	-0.848
N-Acetylornithine	down	0.978	0.669	-2.530