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Theoretical model of how sex and genetic and early-environmental risk factors for schizophrenia-spectrum disorders (SZ) are hypothesized to moderate the influence of pubertal maturation on the development of frontal-limbic & frontal-striatal brain networks, changing the risk for the emergence of psychotic, affective and negative symptoms. The hypothesized pathways are based on the literature discussed in sections 2 to 4 and can be tested using recommendations described in section 5.
