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. Author manuscript; available in PMC: 2023 Dec 16.
Published in final edited form as: Nat Rev Mol Cell Biol. 2023 Mar 15;24(5):334–354. doi: 10.1038/s41580-022-00568-6

Figure 6: Post-translational regulatory mechanisms that control stem cell quiescence.

Figure 6:

Once translated, the native protein can be modified with post-translational modifications such as phosphorylation, glycosylation, and ubiquitination, which affect protein function and turnover. Ubiquitinated proteins can be degraded by the proteasome and the lysosome.

FBW7, f-box and WD repeat domain containing 7; MYC, MYC proto-oncogene; Ub, ubiquitin; MAEA, macrophage erythroblast attacher; LRIG, leucine rich repeats and immunoglobulin like domains; EGFR, epidermal growth factor receptor; ID4, inhibitor of DNA binding 4; ASCL1, achaete-scute family BHLH transcription factor 1; SIRT7, sirtuin 7; NFATC1, nuclear factor of activated T Cells 1; HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.