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. Author manuscript; available in PMC: 2023 Dec 16.
Published in final edited form as: Nature. 2023 Aug 9;620(7975):881–889. doi: 10.1038/s41586-023-06409-6

Extended Data Fig. 8 |. Effect of lactate on EAE.

Extended Data Fig. 8 |

a, EAE development of mice after vehicle injection (n = 9), intraperitoneal (ip) (n = 10), nasal, or intravenous (iv) (n = 5 per group) L-LA or D-LA administration. b, IFNγ+, IFNγ+IL-17+ and IL-17+ CD4+ T cells in CNS isolated from mice from a 28 days after EAE induction (n = 3–4 per group). c–f, Heat map (c), GSEA (d) and IPA (e,f) analysis of RNA-seq of splenic DCs isolated from mice treated with vehicle, L-LA (e) and D-LA (f) 28 days after EAE induction. Statistical analysis was performed using two-way ANOVA for a and one-way ANOVA with Dunnett’s post-hoc test for selected multiple comparisons for b. Data shown as mean ± s.e.m.