Table 2.
Comparison of Symptoms, Clinical Outcomes, and Laboratory Values of Patients With SARS-CoV-2 With SCD and Malignancy
| Malignancy | Sickle Cell Disease | P | ||
|---|---|---|---|---|
| Variable | Categories | (n = 232) | (n = 140) | |
| Fever | No | 171 (73.71) | 63 (45.00) | <.0001 |
| Yes | 61 (26.29) | 77 (55.00) | ||
| Headache | No | 212 (91.38) | 118 (84.29) | .0542 |
| Yes | 20 (8.62) | 22 (15.71) | ||
| Cough | No | 163 (70.26) | 75 (53.57) | .0017 |
| Yes | 69 (29.74) | 65 (46.43) | ||
| Sore throat | No | 215 (92.67) | 122 (87.14) | .1126 |
| Yes | 17 (7.33) | 18 (12.86) | ||
| Loss of taste and smell | No | 218 (93.97) | 132 (94.29) | 1 |
| Yes | 14 (6.03) | 8 (5.71) | ||
| Shortness of breath | No | 224 (96.55) | 129 (92.14) | .1035 |
| Yes | 8 (3.45) | 11 (7.86) | ||
| Diarrhea | No | 219 (94.40) | 136 (97.14) | .3308 |
| Yes | 13 (5.60) | 4 (2.86) | ||
| LRTI/URTI | LRTI | 4 (1.72) | 11 (7.86) | .0137 |
| None | 140 (60.34) | 77 (55.00) | ||
| URTI | 88 (37.93) | 52 (37.14) | ||
| Hospitalization | Already hospitalized | 24 (10.34) | 2 (1.43) | <.0001 |
| No | 194 (83.62) | 105 (75.00) | ||
| Yes | 14 (6.03) | 33 (23.57) | ||
| ICU | No | 35 (15.09) | 31 (22.14) | .1112 |
| Not hospitalized | 194 (83.62) | 105 (75.00) | ||
| Yes | 3 (1.29) | 4 (2.86) | ||
| Death | No | 230 (99.14) | 140 (100.00) | .7115 |
| Yes | 2 (0.86) | 0 (0.00) | ||
| Treatment convalescent Plasma | No | 230 (99.14) | 140 (100.00) | .7115 |
| Yes | 2 (0.86) | 0 (0.00) | ||
| Treatment remdesivir | No | 222 (95.69) | 128 (91.43) | .144 |
| Yes | 10 (4.31) | 12 (8.57) | ||
| Treatment steroid | No | 222 (98.23) | 131 (94.93) | .1415 |
| Yes | 4 (1.77) | 7 (5.07) | ||
| Vaccination | No | 186 (80.17) | 116 (82.86) | .6136 |
| Yes | 46 (19.83) | 24 (17.14) | ||
| Sequencing | Alpha | 9 (3.88) | 3 (2.14) | .6274 |
| Ancestral | 53 (22.84) | 35 (25.00) | ||
| Delta | 32 (13.79) | 13 (9.29) | ||
| Epsilon | 1 (0.43) | 0 (0.00) | ||
| Omicron | 94 (40.52) | 63 (45.00) | ||
| Undetermined | 43 (18.53) | 26 (18.57) | ||
| ALC | Mean (SD) | 1711.14 (1632.60) | 3234.00 (2724.69) | <.0001 |
| Median (IQR) | 1268.50 [519.75, 2382.50] | 2762.50 [1705.25, 3693.50] | <.0001 | |
| Log10 IU/mL SARS-CoV-2 N1 | Mean (SD) | 4.59 (1.87) | 4.41 (1.77) | .3548 |
| Median (IQR) | 4.37 [2.49, 6.34] | 4.06 [2.49, 5.84] | .4803 |