FIGURE 5.

Simulation results with worst‐case scenario predictions of doxorubicin exposure in a population of 500 infants between 0 and 1 years old. Concentration‐time curves (a), AUC_0‐inf (b) and C _max (c) for peripheral venous blood, heart, small and large intestines for the situations in which 0, 1, 2 or 3 days of breast milk are discarded after maternal administration with 90% prediction intervals. The horizontal dashed line represents the lowest in vitro cell death IC₅₀ for doxorubicin found in literature (270 nM, after a 72 h exposure). AUC_0‐inf, area under the plasma‐concentration time curve extrapolated till infinity; C _max, peak concentrations; IC₅₀, half‐maximal inhibitory concentration.